CAGRI

Description

CAGRI Reference Material | Long-Acting Amylin Analog

CAGRI (Cagrilintide) is a synthetic amylin analog and calcitonin receptor (CTR) agonist engineered with amino acid substitutions that increase receptor affinity and resistance to enzymatic degradation. It acts at amylin receptors AMY1, AMY2, and AMY3 (calcitonin receptor + RAMP1/2/3 heterodimers) with an extended receptor occupancy profile suited for chronic satiety circuit stimulation studies.

Laboratory Research Applications

• Amylin receptor (AMY1-3) binding and activation pharmacology
• Gastric emptying rate assay systems
• Glucagon secretion suppression in pancreatic islet preparations
• Hypothalamic satiety circuit and neuropeptide modulation studies
• Combination incretin + amylinergic co-activation studies (with GLP-1R agonists)

Specifications

• Form: Lyophilized powder
• Purity: ≥98% (HPLC verified)
• Storage: 2–8°C; -20°C long-term

For laboratory research use only. Not for human or veterinary use.