5-Amino-1MQ

Description

5-Amino-1MQ Reference Material | NNMT Inhibitor

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a cell-permeable small molecule that functions as a potent, selective inhibitor of Nicotinamide N-methyltransferase (NNMT) — an enzyme central to NAD+ metabolism, one-carbon methylation cycle regulation, and epigenetic control of adipocyte gene expression.

Mechanism of Research Interest

NNMT catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM) as methyl donor, producing 1-methylnicotinamide and S-adenosylhomocysteine. By inhibiting this reaction, 5-Amino-1MQ increases cellular NAD+ availability, alters the SAM/SAH methyl donor ratio, and modulates epigenetic methylation patterns in adipocyte gene regulatory regions. This mechanistic cascade makes it a useful tool in studies of adipogenic differentiation, NAD+ pathway regulation, and epigenetic control of metabolic gene expression.

Laboratory Research Applications

• NNMT enzyme inhibition kinetics and selectivity assays
• NAD+ biosynthesis pathway and cellular NAD+ level studies
• Adipocyte differentiation and adipogenesis gene expression research
• SAM/SAH ratio and methylation cycle studies
• Epigenetic regulation of metabolic gene expression

Specifications

• Form: Lyophilized powder
• Purity: ≥98% (HPLC verified)
• Storage: 2–8°C; protect from light and moisture

For laboratory research use only. Not for human or veterinary use.