ARA-290

Description

ARA-290 Reference Material | Innate Repair Receptor Agonist

ARA-290 is a synthetic 11-residue peptide derived from the helix B surface of erythropoietin (EPO). It selectively activates the Innate Repair Receptor (IRR) — a heterodimer of the EPO receptor and common beta (βc) receptor — without binding the classical EPO homodimer receptor responsible for erythropoiesis. This selectivity is the defining pharmacological feature of ARA-290 as a research tool.

Research Applications

• IRR receptor binding and cytoprotective signaling studies
• Peripheral nerve fiber biology and neuroprotection assay systems
• Pancreatic beta-cell cytoprotection research
• NF-κB anti-inflammatory signaling studies
• Sarcoidosis and autonomic function research models
• Comparative EPO receptor selectivity studies (IRR vs. homodimer)

Specifications

• Form: Lyophilized powder
• Purity: ≥98% (HPLC verified)
• Storage: 2–8°C refrigerated

For laboratory research use only. Not for human or veterinary use.