Gonadorelin

Description

Gonadorelin Reference Material | Synthetic GnRH Decapeptide

Gonadorelin (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2; MW 1,182.31 g/mol) is a synthetic decapeptide identical to endogenous gonadotropin-releasing hormone (GnRH). It is used as a reference ligand for GnRH receptor pharmacology and hypothalamic-pituitary-gonadal (HPG) axis research.

Mechanism of Research Interest

Gonadorelin binds GnRH receptors on anterior pituitary gonadotrophs, triggering pulsatile LH and FSH secretion. Pulsatile vs. continuous GnRH receptor stimulation produces mechanistically distinct responses — pulsatile stimulation maintains LH/FSH secretion while continuous stimulation causes receptor downregulation — making Gonadorelin a useful tool for studying receptor desensitization kinetics and gonadotropin secretion dynamics.

Laboratory Research Applications

• GnRH receptor binding and gonadotroph activation studies
• LH and FSH secretion kinetics in pituitary cell preparations
• HPG axis pulsatility research and gonadotropin regulation
• GnRH receptor desensitization and downregulation studies
• Comparative GnRH agonist/antagonist pharmacology

Specifications

• Sequence: pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
• Molecular Weight: 1,182.31 g/mol
• Form: Lyophilized powder
• Purity: ≥98% (HPLC verified)
• Storage: 2–8°C refrigerated

For laboratory research use only. Not for human or veterinary use.