VIP

Description

VIP Reference Material | Vasoactive Intestinal Peptide

VIP (Vasoactive Intestinal Peptide; MW 3,325.86 g/mol) is a 28-amino acid neuropeptide acting through three GPCRs: VPAC1, VPAC2, and PAC1. All three activate adenylyl cyclase and elevate intracellular cAMP. VIP’s extensive receptor distribution — expressed in neuronal, immune, pulmonary, gastrointestinal, and cardiovascular tissue — makes it a high-utility reference ligand for multi-system preclinical research.

Laboratory Research Applications

• VPAC1/VPAC2 receptor pharmacology and cAMP signaling studies
• Pro-inflammatory cytokine suppression assays (TNF-α, IL-6, IL-12)
• Th1/Th2 immune balance and regulatory T-cell research
• Pulmonary biology — bronchial smooth muscle and airway research models
• Neuroinflammation and mast cell regulation studies
• CIRS (Chronic Inflammatory Response Syndrome) and TGF-β1 modulation research
• Suprachiasmatic nucleus and circadian rhythm studies

Specifications

• Molecular Weight: 3,325.86 g/mol (28 residues)
• Form: Lyophilized powder
• Purity: ≥98% (HPLC verified)
• Storage: -20°C long-term; 2–8°C working stock

For laboratory research use only. Not for human or veterinary use.