GHK-Cu

Description

GHK-Cu Reference Material | Copper-Binding Tripeptide

GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper(II)) is a naturally occurring copper-binding tripeptide found in human plasma. As a reference material, it is studied in fibroblast biology, gene expression research, and copper-dependent enzyme assay systems.

Research Significance

Microarray studies demonstrate GHK-Cu’s capacity to modulate expression of a significant proportion of human genes in fibroblast preparations — including upregulation of collagen I, collagen III, elastin, and glycosaminoglycan synthesis genes, and downregulation of pro-inflammatory cytokine networks. Its copper coordination chemistry makes it relevant to lysyl oxidase and superoxide dismutase enzyme activity research.

Laboratory Research Applications

• Fibroblast collagen and elastin gene expression assays
• TGF-β pathway interaction studies
• Copper-dependent enzyme (lysyl oxidase, SOD) activity research
• TNF-α and IL-6 cytokine modulation in cell culture systems
• Wound biology and keratinocyte migration assays
• Antioxidant signaling pathway studies

Specifications

• Structure: Gly-His-Lys complexed with Cu(II)
• Form: Lyophilized powder
• Purity: ≥98% (HPLC verified)
• Appearance: Blue-tinted powder (characteristic copper complex)
• Storage: 2–8°C; protect from light and moisture

For laboratory research use only. Not for human or veterinary use.