IGF-1 LR3

Description

IGF-1 LR3 Reference Material | Extended Half-Life IGF-1 Analog

IGF-1 LR3 (Long Arg3 IGF-1; MW ~9,200 Da; 83 residues) is a modified insulin-like growth factor 1 analog with an arginine substitution at position 3 and a 13-residue N-terminal extension. These modifications reduce binding affinity to IGF-binding proteins (IGFBPs) by approximately 1,000-fold, extending the biological half-life from ~10 minutes (native IGF-1) to 20–30 hours — making it the most practical IGF-1R reference ligand for studies requiring sustained receptor activation.

Laboratory Research Applications

• IGF-1 receptor (IGF-1R) binding kinetics and activation studies
• PI3K/Akt/mTOR signaling pathway research
• Satellite cell activation and myotube formation assay systems
• Insulin receptor substrate (IRS-1/IRS-2) phosphorylation studies
• IGFBP competition assays and serum binding protein research
• Cartilage and connective tissue biology research
• Cancer biology — IGF-1R signaling in cell proliferation assays

Specifications

• Molecular Weight: ~9,200 Da (83 residues)
• Form: Lyophilized powder
• Purity: ≥98% (HPLC verified)
• Storage: -20°C long-term; 2–8°C working stock

For laboratory research use only. Not for human or veterinary use.