Ipamorelin

Description

Ipamorelin Reference Material | Selective GHSR-1a Agonist

Ipamorelin (Aib-His-D-2Nal-D-Phe-Lys-NH2; MW 711.87 g/mol) is a synthetic pentapeptide and third-generation ghrelin receptor (GHSR-1a) agonist. Its defining pharmacological characteristic is selectivity — GHSR-1a activation without meaningful activity at ACTH, cortisol, or prolactin-secreting pathways — making it the preferred GHSR-1a reference ligand in studies requiring clean somatotroph GH secretion data.

Selectivity Profile

First-generation GHRPs (GHRP-6) activate cortisol and appetite pathways. Second-generation (GHRP-2) retains cortisol and prolactin effects. Ipamorelin’s structural modifications — incorporating non-natural amino acids — confer GHSR-1a selectivity that eliminates these confounding receptor interactions, producing isolated GH secretagogue activity for cleaner research data.

Laboratory Research Applications

• GHSR-1a receptor binding and activation studies
• Selective GH secretion without cortisol pathway interference
• Somatotroph calcium signaling (phospholipase C pathway) research
• Comparative GHRP receptor selectivity profiling
• GI motility studies (GHSR-1a is expressed in gut tissue)
• Combination somatotroph studies with GHRH receptor ligands

Specifications

• Sequence: Aib-His-D-2Nal-D-Phe-Lys-NH2
• Molecular Weight: 711.87 g/mol
• Form: Lyophilized powder
• Purity: ≥99% (HPLC verified)
• Storage: 2–8°C refrigerated

For laboratory research use only. Not for human or veterinary use.