KPV

Description

KPV Reference Material | Alpha-MSH C-Terminal Tripeptide

KPV (Lys-Pro-Val; MW 328.41 g/mol) is the C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone. Its small molecular size confers cell permeability — enabling direct intracellular access to NF-κB pathway components — a mechanistic distinction from larger anti-inflammatory peptides that operate at cell surface receptors.

Mechanism of Research Interest

KPV inhibits NF-κB activation at the intracellular level, reducing downstream pro-inflammatory cytokine transcription (IL-1β, TNF-α, IL-6). Its cell-permeable nature and stability in gastric environments have made it a subject of interest in mucosal biology research, where intracellular delivery of anti-inflammatory signals is mechanistically significant.

Laboratory Research Applications

• Intracellular NF-κB pathway inhibition studies
• Cytokine modulation in epithelial and fibroblast cell culture
• Gastrointestinal mucosal barrier and tight junction research
• Colonic tissue inflammatory response models
• Oral peptide stability and delivery research
• Comparative alpha-MSH fragment activity studies

Specifications

• Sequence: Lys-Pro-Val
• Molecular Weight: 328.41 g/mol
• Form: Lyophilized powder
• Purity: ≥98% (HPLC verified)
• Storage: 2–8°C; -20°C long-term

For laboratory research use only. Not for human or veterinary use.