Melanotan I (MT-1)

Description

Melanotan I (Afamelanotide) Reference Material | Selective MC1R Agonist

Melanotan I (Afamelanotide; [Nle4,D-Phe7]-α-MSH; MW 1,646.90 g/mol) is a synthetic alpha-MSH analog that selectively activates MC1R on melanocytes with minimal activity at MC3R, MC4R, or MC5R. This receptor selectivity makes it the reference compound of choice for isolated melanogenesis and pigmentation pathway research without confounding multi-receptor activation.

Mechanistic Research Focus

MC1R activation on melanocytes triggers cAMP elevation and PKA-mediated transcription factor activation (MITF upregulation), leading to tyrosinase enzyme upregulation and eumelanin synthesis. Melanotan I’s linear structure with stabilizing amino acid substitutions (Nle4, D-Phe7) extends its half-life compared to native α-MSH, enabling sustained MC1R occupancy studies.

Laboratory Research Applications

• MC1R receptor pharmacology and melanogenesis signaling
• Tyrosinase enzyme activity and eumelanin synthesis assays
• Photoprotection biology and UV-induced DNA damage research
• Pigmentation disorder research models (vitiligo, EPP)
• Comparative melanocortin agonist selectivity (MT-1 vs. MT-2 vs. PT-141)

Specifications

• Also Known As: Afamelanotide, [Nle4,D-Phe7]-α-MSH
• Molecular Weight: 1,646.90 g/mol
• Form: Lyophilized powder
• Purity: ≥98% (HPLC verified)
• Storage: 2–8°C; protect from light

For laboratory research use only. Not for human or veterinary use.