Selank

Description

Selank Reference Material | Tuftsin-Derived Anxiolytic Heptapeptide

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro; MW 751.87 g/mol) is a synthetic heptapeptide derived from the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg). It is supplied as a lyophilized reference material for preclinical neuropharmacology, neurotrophin, and immunomodulation research.

Research Profile

Selank’s preclinical research profile spans GABA-A receptor modulation (anxiolytic mechanism without receptor downregulation), BDNF and NGF neurotrophin upregulation in hippocampal preparations, serotonergic system modulation, and IL-6/interferon cytokine network regulation. This multi-target profile makes it a useful reference compound for researchers studying the intersection of anxiety circuitry, neurotrophin biology, and immune signaling.

Laboratory Research Applications

• GABA-A receptor modulation studies (benzodiazepine-site independent)
• BDNF and NGF expression assays in hippocampal and cortical tissue
• IL-6, interferon, and T-lymphocyte activity research
• Enkephalin stabilization and opioid system interaction studies
• HPA axis and stress response research models
• Comparative anxiolytic pharmacology studies

Specifications

• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
• Molecular Weight: 751.87 g/mol
• Form: Lyophilized powder
• Purity: ≥98% (HPLC verified)
• Storage: 2–8°C; -20°C long-term

For laboratory research use only. Not for human or veterinary use.