Semax

Description

Semax Reference Material | ACTH-Derived Heptapeptide

Semax (Met-Glu-His-Phe-Pro-Gly-Pro; MW 813.94 g/mol) is a synthetic heptapeptide derived from the ACTH(4-7) sequence with a C-terminal Pro-Gly-Pro extension. It is supplied as a lyophilized reference material for preclinical neuroscience and neuroprotection research.

Mechanism of Interest

Semax does not stimulate adrenal cortisol release. Its preclinical research profile centers on BDNF and NGF neurotrophin upregulation in hippocampal and cortical tissue preparations, modulation of the dopaminergic and serotonergic systems, and neuroprotective effects in ischemic brain injury models.

Laboratory Research Applications

• BDNF and NGF neurotrophin expression studies in CNS tissue
• Dopaminergic neurotransmitter system modulation assays
• Ischemic brain injury and neuroprotection research models
• Attention and learning-related behavioral pharmacology paradigms
• HPA axis and stress response research (non-cortisol pathway)
• Enkephalin and opioid system interaction studies

Specifications

• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (ACTH 4-7 + PGP)
• Molecular Weight: 813.94 g/mol
• Form: Lyophilized powder
• Purity: ≥98% (HPLC verified)
• Storage: 2–8°C; -20°C long-term

For laboratory research use only. Not for human or veterinary use.