SNAP-8

Description

SNAP-8 Reference Material | Acetyl Octapeptide-3 / SNARE Complex Inhibitor

SNAP-8 (Acetyl Octapeptide-3; Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2; MW 1,075.20 g/mol) is a synthetic peptide that mimics and competes with SNAP-25 — a core component of the SNARE complex mediating synaptic vesicle fusion at the neuromuscular junction. As a SNARE complex research tool, SNAP-8 provides a reversible, dose-dependent model of acetylcholine release inhibition for mechanistic neuroscience research.

Mechanism of Research Interest

SNARE complex formation (involving Syntaxin, SNAP-25, and VAMP/Synaptobrevin) is essential for synaptic vesicle fusion and neurotransmitter exocytosis. SNAP-8 competes with SNAP-25 for SNARE complex assembly, partially blocking the conformational changes required for vesicle fusion — producing graded inhibition of acetylcholine release dependent on compound concentration.

Laboratory Research Applications

• SNARE complex assembly kinetics and disruption assays
• Acetylcholine release quantification at neuromuscular junction preparations
• Reversible SNAP-25 competitive inhibition studies
• Comparison with botulinum toxin SNAP-25 cleavage mechanisms
• Wrinkle biology — expression line formation research models

Specifications

• INCI Name: Acetyl Octapeptide-3
• Molecular Weight: 1,075.20 g/mol
• Form: Lyophilized powder
• Purity: ≥98% (HPLC verified)
• Storage: 2–8°C; protect from light and moisture

For laboratory research use only. Not for human or veterinary use.