TB-500

Description

TB-500 Reference Material | Thymosin Beta-4 Fragment

TB-500 is a synthetic peptide corresponding to the actin-binding domain of Thymosin Beta-4 — the fragment Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (MW 888.04 g/mol). As a lyophilized reference material, TB-500 is supplied for use in preclinical cell biology, ECM remodeling, and angiogenesis research.

Molecular Characterization

TB-500 regulates G-actin/F-actin equilibrium through G-actin sequestration — the primary mechanism underlying its effects on cell motility and migration in research models. Additional documented activities include MMP-2 (matrix metalloproteinase-2) upregulation and VEGF-mediated angiogenic signaling modulation.

Laboratory Research Applications

• G-actin sequestration and actin dynamics studies in cell culture
• Fibroblast and endothelial cell migration assays
• MMP-2 expression and basement membrane remodeling studies
• Systemic angiogenesis research in preclinical animal models
• Cardiac tissue biology and ischemia research models
• Inflammatory cytokine (TNF-α, IL-6) modulation assays

Specifications

• Active Fragment: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln
• Molecular Weight: 888.04 g/mol
• Form: Lyophilized powder
• Purity: ≥99% (HPLC verified)
• Storage: 2–8°C refrigerated

For laboratory research use only. Not for human or veterinary use.