Thymosin Alpha-1

Description

Thymosin Alpha-1 Reference Material | Immunomodulatory Thymic Peptide

Thymosin Alpha-1 (Tα1; MW 3,108.34 g/mol) is a 28-amino acid N-terminal acetylated peptide derived from Thymosin Fraction 5. It is among the most clinically validated immunomodulatory peptides, with regulatory approval in over 35 countries for chronic viral hepatitis, providing an extensive pharmacological and immunological reference dataset for researchers.

Mechanism of Research Interest

Thymosin Alpha-1 activates Toll-like receptors (TLR2, TLR9) on dendritic cells and macrophages, triggering innate immune pathway activation and Th1 cytokine polarization (IL-2, IFN-γ, IL-12, TNF-α upregulation). In T-cell research, it promotes thymocyte maturation and differentiation. Its dual innate/adaptive immune modulation profile makes it a reference compound for immunology assay design.

Laboratory Research Applications

• T-cell and dendritic cell maturation assays
• TLR2/TLR9 pathway activation studies
• Th1/Th2 cytokine balance and immune polarization research
• Antiviral immune response models (hepatitis B/C, influenza)
• Tumor immunology and immune evasion research
• Post-immunosuppression immune reconstitution studies

Specifications

• Molecular Weight: 3,108.34 g/mol (28 residues, N-acetylated)
• Form: Lyophilized powder
• Purity: ≥99% (HPLC verified)
• Storage: 2–8°C; -20°C long-term

For laboratory research use only. Not for human or veterinary use.